Young cancer patients who couldn't get a key medicine because of a national drug shortage were more likely to suffer a relapse than others who were able to get the preferred treatment, doctors report. It's the first evidence that a long-standing drug-supply problem probably has affected cancer treatment results in specific patients.
The study involved more than 200 children and young adults with a blood cancer called Hodgkin lymphoma. Like childhood leukemia, it can be cured nearly 80 percent of the time. But a drug shortage that has worsened since 2009 is threatening that success rate, doctors reported in Thursday's New England Journal of Medicine.
The new study, led by Dr. Monika Metzger of St. Jude Children's Research Hospital in Memphis, focused on mechlorethamine, or nitrogen mustard, a drug that had been in short supply until last month, when more became available. Doctors compared results among 181 Hodgkin lymphoma patients who received the drug to 40 others who were given a different chemotherapy, cyclophosphamide, when the first choice was unavailable.
Only 75 percent of those given the substitute drug stayed free of cancer for two years versus 88 percent who received the preferred treatment.
“We can think of no credible explanation for this dramatic difference” other than the drug substitution, the authors wrote.
No patients died, but those who relapsed were given more aggressive treatments, including stem-cell transplants that have more side effects and can harm fertility.